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Silane USi-6307 – Trimethylchlorosilane (TMCS)
Highly Reactive Chlorosilane for Silylation, End-Capping & Derivatization
CAS No.: 75-77-4
EINECS No.: 200-900-5
Molecular Weight: 108.64 g/mol
Chemical Name:
Trimethylchlorosilane
Synonyms:
TMCS; Trimethylsilyl chloride; CSISilane USi-6307 is a high-purity trimethylchlorosilane (TMCS)—a compact, highly reactive chloro-functional silane featuring three methyl groups and one chlorine atom bonded to silicon. Widely used as a powerful silylating agent, it rapidly caps hydroxyl (–OH), carboxyl (–COOH), and amine (–NH) groups in organic, biochemical, and silicone systems. Essential for moisture protection, volatility enhancement in GC/MS, and end-blocking of siloxane polymers.
🧪 Product Description
Chemical Formula: (CH₃)₃SiCl
Chemical Structure:
![Structure: (CH₃)₃–Si–Cl]USi-6307 is a versatile reagent valued for its speed and efficiency:
- Reacts instantly with moisture to form hexamethyldisiloxane (HMDSO)—making it an effective moisture scavenger in sensitive reactions
- Silylates polar functional groups in pharmaceuticals, steroids, sugars, and amino acids—improving volatility, thermal stability, and chromatographic resolution for GC/MS analysis
- Acts as a chain terminator in silicone synthesis, capping reactive silanol (Si–OH) ends to control molecular weight and prevent gelation
- Key precursor for synthesizing hexamethyldisiloxane (HMDSO) and hexamethyldisilazane (HMDS)—widely used solvents and reagents in semiconductor and chemical industries
⚠️ Critical Note: TMCS is extremely moisture-sensitive, corrosive, and toxic. It reacts violently with water, releasing hydrogen chloride (HCl) gas. It is not a coupling agent—but a specialty reagent for controlled silylation under anhydrous conditions.
📊 Typical Technical Data
The following values are typical and not intended for specification. Please confirm with our technical team before finalizing product requirements.
Parameter Specification Appearance Colorless transparent liquid Silicon Tetrachloride ≤ 0.03% Purity (GC, %) ≥ 99.0%
🏭 Key Applications
🔹 Silylation Reagent in Analytical Chemistry
- Derivatizes polar biomolecules (e.g., sugars, fatty acids, phenols) for GC/MS or HPLC analysis
- Enhances peak shape, sensitivity, and thermal stability of analytes
🔹 End-Capping Agent in Silicone Manufacturing
- Terminates silanol-terminated PDMS chains to produce stable, non-reactive silicone oils and fluids
- Prevents post-condensation and viscosity drift during storage
🔹 Moisture Scavenger in Anhydrous Reactions
- Removes trace water from reaction mixtures by converting it to volatile HMDSO and HCl
- Used in Grignard, organolithium, and other moisture-sensitive syntheses
🔹 Intermediate for High-Purity Silicones
- Primary raw material for producing hexamethyldisiloxane (HMDSO) and hexamethyldisilazane (HMDS)—key building blocks in electronics-grade silicones and CVD precursors
🔹 Protecting Group in Organic Synthesis
- Temporarily masks alcohols, phenols, and carboxylic acids during multi-step syntheses
- Easily removed under mild acidic or basic conditions
⚠️ Critical Safety & Handling Notes
- Extremely hazardous: Reacts violently with water/moisture, releasing toxic and corrosive HCl gas
- Flammable and corrosive: Causes severe skin/eye burns and respiratory irritation
- Storage: Must be kept in original sealed containers, under dry inert atmosphere (e.g., nitrogen), in a cool, dry, well-ventilated area, away from incompatible materials
- Shelf Life: 12 months when stored between –40°C and +40°C in unopened containers
- PPE Required: Chemical-resistant gloves, face shield, acid gas respirator, and fume hood operation mandatory
- SDS Essential: Always review the latest Safety Data Sheet at www.usi-chemical.com or upon request before handling
📦 Packaging
Supplied in corrosion-resistant, moisture-tight industrial containers:
- 25 L pail
- 170 kg drum
- 1000 L IBC tote
All packaging is designed for safe transport and storage of reactive chlorosilanes.
📞 Contact Us
Nanjing Union Silicon Chemical Co., Ltd.
Global Supplier of High-Purity Trimethylchlorosilane (TMCS) for Pharma, Analytics & Silicone Industries- Headquarters:
Room 2002, Overseas Chinese Plaza, No.1 Daqiao North Road, Nanjing 210031, Jiangsu, P.R. China - Factory Address:
Dongcheng Guanli District, Gaizhou 115200, Liaoning, P.R. China - Tel: +86-25-5889 5266 / 5889 5699
- Fax: +86-25-5830 5349
- Website: www.usi-chemical.com
- Email: inquiry@usichemical.com
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